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However, because of extremely rapid plasma clearance time, instability, and immunogenicity in vivo, the clinical application of SOD as a therapeutic agent has been very limited [122]

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[PUBMED Abstract] Myers RM, Taraseviciute A, Steinberg SM, et al.: Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL